Mitch Brinkkemper

Oct 3, 2024 | journals.plos.org | Mitch Brinkkemper |Amsterdam UMC |Gius Kerster |PLOS Pathogens

Loading metrics Open Access Peer-reviewedResearch Article Citation: Brinkkemper M, Kerster G, Brouwer PJM, Tran AS, Torres JL, Ettema RA, et al. (2024) Mosaic and mixed HIV-1 glycoprotein nanoparticles elicit antibody responses to broadly neutralizing epitopes. PLoS Pathog 20(10): e1012558. https://doi.org/10.1371/journal.ppat.1012558Editor: Penny L.

May 9, 2024 | biorxiv.org | Denise Guerra |Laura Radić |Mitch Brinkkemper |Meliawati Poniman

AbstractMonoclonal neutralizing antibodies (mAbs) are considered an important prophylactic against SARS-CoV-2 infection in at-risk populations and a strategy to counteract future sarbecovirus-induced disease. However, most mAbs isolated so far neutralize only a few sarbecovirus strains. Therefore, there is a growing interest in bispecific antibodies (bsAbs) which can simultaneously target different spike epitopes and thereby increase neutralizing breadth and prevent viral escape.