Mitsuhiko Ikura

May 15, 2024 | onlinelibrary.wiley.com | Masahiro Enomoto |Christopher Marshall |Mitsuhiko Ikura |Ningdi F. Liu

1 INTRODUCTION RAF kinase activation is a complex regulatory step within the fundamental RAS-RAF-MEK-ERK (RAS-MAPK) pathway that controls growth, differentiation, division, and proliferation. Five RAF family members are present in vertebrates: ARAF, BRAF and CRAF (RAF1) in addition to the pseudokinases KSR1/2.