Mohammed El-Kebir

Nov 18, 2024 | biorxiv.org | Leah Weber |Anna Hart |Idoia Ochoa |Mohammed El-Kebir

AbstractCancer arises through an evolutionary process in which somatic mutations, including single nucleotide variants (SNVs) and copy number aberrations (CNAs), drive the development of a malignant, heterogeneous tumor. Reconstructing this evolutionary history from sequencing data is critical for understanding the order in which mutations are acquired and the dynamic interplay between different types of alterations.

Oct 11, 2023 | journals.plos.org | Leah Weber |Chuanyi Zhang |Idoia Ochoa |Mohammed El-Kebir

Loading metrics Open Access Peer-reviewedResearch Article ? This is an uncorrected proof. Citation: Weber LL, Zhang C, Ochoa I, El-Kebir M (2023) Phertilizer: Growing a clonal tree from ultra-low coverage single-cell DNA sequencing of tumors. PLoS Comput Biol 19(10): e1011544. https://doi.org/10.1371/journal.pcbi.1011544Editor: Teresa M.