Mojun Shen

Nov 14, 2023 | nature.com | Eamon Fitzgerald |Mojun Shen |Sachin Patel |Shiao-Yng Chan |Peter D Gluckman

AbstractPathological placental inflammation increases the risk for several adult disorders, but these mediators are also expressed under homeostatic conditions, where their contribution to adult health outcomes is unknown. Here we define an inflammation-related expression signature, primarily expressed in Hofbauer cells of the term placenta and use expression quantitative trait loci to create a polygenic score (PGS) predictive of its expression.