Shiao-Yng Chan

Nov 14, 2023 | nature.com | Eamon Fitzgerald |Mojun Shen |Sachin Patel |Shiao-Yng Chan |Peter D Gluckman

AbstractPathological placental inflammation increases the risk for several adult disorders, but these mediators are also expressed under homeostatic conditions, where their contribution to adult health outcomes is unknown. Here we define an inflammation-related expression signature, primarily expressed in Hofbauer cells of the term placenta and use expression quantitative trait loci to create a polygenic score (PGS) predictive of its expression.

Feb 3, 2023 | nature.com | Jian Huang |Keith Godfrey |Anqi Qiu |Kok Hian Tan |Shiao-Yng Chan

Data SourceThis study was conducted within the Singapore PREconception Study of long-Term maternal and child Outcomes (S-PRESTO) cohort [21]. In brief, between February 2015 and October 2017, S-PRESTO recruited 1032 non-pregnant women aged 18 to 45 years (mean = 31, standard deviation (SD) = 3.7) of Chinese, Malay or Indian ethnicity who intended to conceive and deliver in Singapore. Participants were followed for up to 3 preconception visits and censored at 12 months if they did not conceive.