Mona A. Chalmer

Oct 26, 2023 | nature.com | Gyda Bjornsdottir |Mona A. Chalmer |Astros Th. Skuladottir |Gudmundur Einarsson |Egil Ferkingstad |Solveig Gretarsdottir | +27 more

AbstractMigraine is a complex neurovascular disease with a range of severity and symptoms, yet mostly studied as one phenotype in genome-wide association studies (GWAS). Here we combine large GWAS datasets from six European populations to study the main migraine subtypes, migraine with aura (MA) and migraine without aura (MO). We identified four new MA-associated variants (in PRRT2, PALMD, ABO and LRRK2) and classified 13 MO-associated variants.