Egil Ferkingstad

Aug 4, 2024 | nature.com | Molly Went |Gísli H. Halldórsson |Andrea Gunnell |Philip J Law |Amit Sud |Gudmar Thorleifsson | +24 more

AbstractMultiple myeloma (MM) is an incurable malignancy of plasma cells. Epidemiological studies indicate a substantial heritable component, but the underlying mechanisms remain unclear. Here, in a genome-wide association study totaling 10,906 cases and 366,221 controls, we identify 35 MM risk loci, 12 of which are novel.

Oct 26, 2023 | nature.com | Gyda Bjornsdottir |Mona A. Chalmer |Astros Th. Skuladottir |Gudmundur Einarsson |Egil Ferkingstad |Solveig Gretarsdottir | +27 more

AbstractMigraine is a complex neurovascular disease with a range of severity and symptoms, yet mostly studied as one phenotype in genome-wide association studies (GWAS). Here we combine large GWAS datasets from six European populations to study the main migraine subtypes, migraine with aura (MA) and migraine without aura (MO). We identified four new MA-associated variants (in PRRT2, PALMD, ABO and LRRK2) and classified 13 MO-associated variants.

Jul 3, 2023 | nature.com | Asmundur Oddsson |Patrick Sulem |Gardar Sveinbjornsson |Gudny A. Arnadottir |Valgerdur Steinthorsdottir |Gísli H. Halldórsson | +41 more

Author notesThese authors contributed equally: Asmundur Oddsson, Patrick Sulem. These authors jointly supervised this work: Kari Stefansson, Daniel F. Gudbjartsson. Authors and AffiliationsdeCODE genetics/Amgen, Inc., Reykjavik, IcelandAsmundur Oddsson, Patrick Sulem, Gardar Sveinbjornsson, Gudny A. Arnadottir, Valgerdur Steinthorsdottir, Gisli H. Halldorsson, Bjarni A. Atlason, Gudjon R. Oskarsson, Hannes Helgason, Hildigunnur Katrinardottir, Run Fridriksdottir, Brynjar O.

Jun 10, 2023 | nature.com | Asmundur Oddsson |Patrick Sulem |Gardar Sveinbjornsson |Gudny A. Arnadottir |Valgerdur Steinthorsdottir |Gísli H. Halldórsson | +41 more

Study samples and ethics declarationsFor Iceland, this study is based on whole-genome sequence data from the white blood cells of 49,708 Icelanders participating in various disease projects at deCODE Genetics14. In addition, a total of 155,250 Icelanders have been genotyped using Illumina SNP chips. All participating individuals who donated blood or buccal tissue samples, or their guardians, provided written informed consent.