Morag Park

Oct 23, 2024 | nature.com | Alexandre Poirier |Anne-Marie N. Fortier |Nancy Lin |Morag Park |Michel Tremblay |Rinath Jeselsohn

AbstractRecurrent breast cancers often develop resistance to standard-of-care therapies. Identifying targetable factors contributing to cancer recurrence remains the rate-limiting step in improving long-term outcomes. In this study, we identify tumor cell-derived osteopontin as an autocrine and paracrine driver of tumor recurrence. Osteopontin promotes tumor cell proliferation, recruits macrophages, and synergizes with IL-4 to further polarize them into a pro-tumorigenic state.

Jun 7, 2024 | nature.com | Antoine Khalil |Daan A. Smits |Thijs Koorman |Mathijs Verhagen |Daan Visser |Anne-Marie N. Fortier | +5 more

AbstractDense and aligned Collagen I fibers are associated with collective cancer invasion led by protrusive tumor cells, leader cells. In some breast tumors, a population of cancer cells (basal-like cells) maintain several epithelial characteristics and express the myoepithelial/basal cell marker Keratin 14 (K14). Emergence of leader cells and K14 expression are regarded as interconnected events triggered by Collagen I, however the underlying mechanisms remain unknown.

Jan 25, 2024 | mdpi.com | Abdulhameed Al-Ghabkari |Bruce Huang |Morag Park

All articles published by MDPI are made immediately available worldwide under an open access license. No specialpermission is required to reuse all or part of the article published by MDPI, including figures and tables. Forarticles published under an open access Creative Common CC BY license, any part of the article may be reused withoutpermission provided that the original article is clearly cited. For more information, please refer tohttps://www.mdpi.com/openaccess.

May 20, 2023 | nature.com | Jeffrey Trent |Gregg B. Morin |Morag Park |William D. Foulkes |Yemin Wang |Gian L. Negri | +1 more

All research in this study complies with all relevant ethical regulations. All biohazard protocols were approved by the Environmental Health and Safety of McGill University and the Biosafety Committee of the University of British Columbia (UBC). All animal procedures were approved by the Facility Animal Care Committee (FACC) of McGill University and the Animal Care Committee of UBC, according to guidelines of the Canadian Council on Animal Care Standards (CCAC).