Thijs Koorman

Jul 19, 2024 | nature.com | Steffi Oesterreich |Adrian Lee |Fangyuan Chen |Rachel C. Jankowitz |Rita A. Mukhtar |Matthew J Sikora | +3 more

AbstractThere is growing awareness of the unique etiology, biology, and clinical presentation of invasive lobular breast cancer (ILC), but additional research is needed to ensure translation of findings into management and treatment guidelines. We conducted a survey with input from breast cancer physicians, laboratory-based researchers, and patients to analyze the current understanding of ILC, and identify consensus research questions.

Jun 7, 2024 | nature.com | Antoine Khalil |Daan A. Smits |Thijs Koorman |Mathijs Verhagen |Daan Visser |Anne-Marie N. Fortier | +5 more

AbstractDense and aligned Collagen I fibers are associated with collective cancer invasion led by protrusive tumor cells, leader cells. In some breast tumors, a population of cancer cells (basal-like cells) maintain several epithelial characteristics and express the myoepithelial/basal cell marker Keratin 14 (K14). Emergence of leader cells and K14 expression are regarded as interconnected events triggered by Collagen I, however the underlying mechanisms remain unknown.