Morten A. Karsdal

Jul 1, 2023 | mdpi.com | Federica Genovese |Peder Frederiksen |Anne-Christine Bay-Jensen |Morten A. Karsdal

Abstract:Nitisinone has been approved for treatment of alkaptonuria (AKU). Non-invasive biomarkers of joint tissue remodelling could aid in understanding the molecular changes in AKU pathogenesis and how these can be affected by treatment. Serological and urinary biomarkers of type I collagen and II collagen in AKU were investigated in patients enrolled in the randomized SONIA 2 (NCT01916382) clinical study at baseline and yearly until the end of the study (Year 4).

May 24, 2023 | mdpi.com | Yunyun Luo |Martin Pehrsson |Lasse L. Langholm |Morten A. Karsdal

Abstract:Immunoassays, which have gained popularity in clinical practice and modern biomedical research, play an increasingly important role in quantifying various analytes in biological samples. Despite their high sensitivity and specificity, as well as their ability to analyze multiple samples in a single run, immunoassays are plagued by the problem of lot-to-lot variance (LTLV).