Anne-Christine Bay-Jensen

Jan 6, 2025 | nature.com | Martin Pehrsson |Anne-Christine Bay-Jensen |Morten Asser Karsdal |Bent Deleuran |Tue W. Kragstrup |Satoshi KUBO | +2 more

AbstractUnderstanding how inflammatory cytokines influence profibrogenic wound healing responses in fibroblasts is important for understanding the pathogenesis of fibrosis. TNF-α and IL-13 are key cytokines in Th1 and Th2 immune responses, respectively, while TGF-β1 is the principal pro-fibrotic mediator.

Jul 1, 2023 | mdpi.com | Federica Genovese |Peder Frederiksen |Anne-Christine Bay-Jensen |Morten A. Karsdal

Abstract:Nitisinone has been approved for treatment of alkaptonuria (AKU). Non-invasive biomarkers of joint tissue remodelling could aid in understanding the molecular changes in AKU pathogenesis and how these can be affected by treatment. Serological and urinary biomarkers of type I collagen and II collagen in AKU were investigated in patients enrolled in the randomized SONIA 2 (NCT01916382) clinical study at baseline and yearly until the end of the study (Year 4).

May 30, 2023 | mdpi.com | Mylène P. Jansen |Anne-Christine Bay-Jensen |Peder Frederiksen |Stefania Kalogera

1. IntroductionOsteoarthritis (OA) is the most common form of arthritis and is characterized by chronic pain and disability [1]. The main hallmarks of OA include cartilage degradation, osteophyte formation, subchondral bone remodeling, and inflammation of the synovium. Joint pain is the most common clinical OA manifestation; however, the association between structural changes and pain is still not completely understood.

Apr 5, 2023 | onlinelibrary.wiley.com | Simon C. Mastbergen |Anne-Christine Bay-Jensen |Sofie F. Madsen |Helena Port

Abstract Introduction Ankle joint distraction (AJD) is a promising treatment for patients with severe haemophilic ankle arthropathy (HAA). However, some patients showed no clinical improvement after AJD and these differences may be related to structural differences.