Na Yin

Nov 21, 2024 | biorxiv.org | Min Peng |Na Yin |Youguang Wang

AbstractTargeted protein degradation (TPD) relies on molecules engaging host protein degradation machinery. Here, we developed a novel TPD platform based on antigen endocytosis and degradation by chimeric antigen receptor (CAR) T cells. T cells expressing a CAR with TNFR1 as the antigen-binding domain (TNFR1T) were able to bind, endocytose, and degrade TNF in vitro. To enhance in vivo expansion and persistence of TNFR1T cells, BCOR and ZC3H12A were depleted, generating TNFR1TIF cells.

Nov 29, 2023 | pubs.rsc.org | Na Yin |cheng Liu |Yi Ding |Pengfei Yang

Preparation of amino-modified biochar supported sulfide nanoscale zero-valent iron composite and its efficient removal of U(VI) from wastewater by adsorption and reduction Nanoscale zero-valent iron (nZVI) was cured by vulcanization and biochar functionalization to overcome the tendency of oxidation and aggregation, and the sulfurized nano-zero-valent iron functional material supported by amino biochar (SnZVI-BC-NH2) was obtained, which was used to remove U(VI) from wastewater in this study....

Jun 14, 2023 | science.org | Ana B. Lao-Rodríguez |Elizabeth Bowman |Michael Fox |Na Yin

InformationPublished In Science AdvancesVolume 9 | Issue 24June 2023CopyrightCopyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).