Nagireddy Putluri

2 months ago | nature.com | Upasana Sahu |Tae Jin Lee |Benny A. Kaipparettu |Ashok Sharma |Nagireddy Putluri |Christopher D. Willey | +3 more

AbstractIdentification of isocitrate dehydrogenase (IDH) mutations has uncovered the crucial role of metabolism in gliomagenesis. Oncolytic herpes virus (oHSV) initiates direct tumor debulking by tumor lysis and activates anti-tumor immunity, however, little is known about the role of glioma metabolism in determining oHSV efficacy.

Aug 14, 2024 | digitalcommons.library.tmc.edu | Wangie Yu |Yunyun Chen |Nagireddy Putluri |Abdullah Osman

BACKGROUND: Cisplatin (CDDP) is a mainstay treatment for advanced head and neck squamous cell carcinomas (HNSCC) despite a high frequency of innate and acquired resistance. We hypothesised that tumours acquire CDDP resistance through an enhanced reductive state dependent on metabolic rewiring.