Upasana Sahu

2 months ago | nature.com | Upasana Sahu |Tae Jin Lee |Benny A. Kaipparettu |Ashok Sharma |Nagireddy Putluri |Christopher D. Willey | +3 more

AbstractIdentification of isocitrate dehydrogenase (IDH) mutations has uncovered the crucial role of metabolism in gliomagenesis. Oncolytic herpes virus (oHSV) initiates direct tumor debulking by tumor lysis and activates anti-tumor immunity, however, little is known about the role of glioma metabolism in determining oHSV efficacy.