Nanyu Yao

Dec 10, 2024 | pubs.rsc.org | Zhenhua Guan |Hubei Province |Nanyu Yao |Wenling Yuan

Total biosynthesis of cotylenin diterpene glycosides as 14-3-3 protein–protein interaction stabilizers† Cotylenins (CNs) are bioactive fungal diterpene glycosides that exhibit stabilizing activity on 14-3-3 protein–protein interactions (PPIs), which has significant therapeutic potential. Although CNs were isolated as early as 1970, their biosynthetic pathway has remained unclear, and their limited supply has hindered further research.