Nathan O Stitziel

Oct 23, 2024 | nature.com | Junedh Amrute |Tracy M. Yamawaki |Sikander Hayat |Andrea Bredemeyer |In-Hyuk Jung |Andrew Koenig | +9 more

AbstractInflammation and tissue fibrosis co-exist and are causally linked to organ dysfunction1,2. However, the molecular mechanisms driving immune–fibroblast cell communication in human cardiac disease remain unexplored and there are at present no approved treatments that directly target cardiac fibrosis3,4. Here we performed multiomic single-cell gene expression, epitope mapping and chromatin accessibility profiling in 45 healthy donor, acutely infarcted and chronically failing human hearts.

Sep 4, 2023 | cell.com | Jared S. Elenbaas |Mineral Diseases |Paul Lee |Nathan O Stitziel

Highlights Human genomic and proteomic data implicate Sushi, von Willebrand factor type A, epidermal growth factor, and pentraxin domain containing 1 (SVEP1) in the pathogenesis of human chronic disease, including cardiovascular disease, glaucoma, and dementia. SVEP1 is critical for vascular development and appears to promote aging, consistent with the antagonistic pleiotropy theory of aging.