Nathan Salomonis

1 week ago | nature.com | Michael Lape |Daniel J. Schnell |Shannon O’Connor |Nathan Salomonis |Lisa Martin |Leah C. Kottyan

AbstractMany relationships between pathogens and human disease are well-established. However, only a small fraction involve diseases considered non-communicable (NCDs). In this study, we sought to leverage the vast amount of newly available electronic health record data to identify potentially novel pathogen-NCD associations and find additional evidence supporting known associations.

Oct 4, 2024 | nature.com | Maarten WJ Fornerod |Deedra Nicolet |Benjamin Kelly |Krzysztof Mrózek |Jean F. Kloppers |Anne-Cecilia van Marle | +21 more

AbstractGenomic profiles and prognostic biomarkers in patients with acute myeloid leukemia (AML) from ancestry-diverse populations are underexplored. We analyzed the exomes and transcriptomes of 100 patients with AML with genomically confirmed African ancestry (Black; Alliance) and compared their somatic mutation frequencies with those of 323 self-reported white patients with AML, 55% of whom had genomically confirmed European ancestry (white; BeatAML).

Mar 21, 2024 | scienceblog.cincinnatichildrens.org | Nathan Salomonis

Thanks to an unusual application of game theory and machine learning technology, a large team of scientists led by experts at Cincinnati Children’s has published the world’s most detailed “atlas” of the many types of stem cells and early progenitors involved in producing human blood from diverse donors.