Navneet Matharu

Apr 19, 2024 | biorxiv.org | Nadav Ahituv |Navneet Matharu |Jingjing Zhao |Ajuni Sohota

AbstractThe human genome contains millions of retrotransposons, several of which could become active due to somatic mutations having phenotypic consequences, including disease. However, it is not thoroughly understood how nucleotide changes in retrotransposons affect their jumping activity. Here, we developed a novel massively parallel jumping assay (MPJA) that can test the jumping potential of thousands of transposons en masse.