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Sep 17, 2024 | 
nature.com | Florence M. Chardon |Riza M. Daza |Diego Calderon |Lea M. Starita |Nadav Ahituv
AbstractCRISPR-based gene activation (CRISPRa) is a strategy for upregulating gene expression by targeting promoters or enhancers in a tissue/cell-type specific manner. Here, we describe an experimental framework that combines highly multiplexed perturbations with single-cell RNA sequencing (sc-RNA-seq) to identify cell-type-specific, CRISPRa-responsive cis-regulatory elements and the gene(s) they regulate.
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Apr 19, 2024 | 
biorxiv.org | Nadav Ahituv |Navneet Matharu |Jingjing Zhao |Ajuni Sohota
AbstractThe human genome contains millions of retrotransposons, several of which could become active due to somatic mutations having phenotypic consequences, including disease. However, it is not thoroughly understood how nucleotide changes in retrotransposons affect their jumping activity. Here, we developed a novel massively parallel jumping assay (MPJA) that can test the jumping potential of thousands of transposons en masse.
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Feb 26, 2024 | 00055-2?rss=yes&sz=64)
cell.com | Chenyu Wang |Kimberly D Derderian |Elizabeth Hamada |Xujia Zhou |Andrew Nelson |Henry Kyoung | +3 more
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Feb 11, 2024 | 
asbmb.org | Wei Gordon |Nadav Ahituv |s Nadav Ahituv
News New understanding of how they’ve adapted to a high-sugar diet could lead to treatments for people By Wei Gordon and Nadav Ahituv People around the world eat too much sugar. When the body is unable to process sugar effectively, leading to excess glucose in the blood, this can result in diabetes. According to the World Health Organization, diabetes became the ninth leading cause of death in 2019. Humans are not the only mammals that love sugar. Fruit bats do, too, eating up to twice their...
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Jan 26, 2024 | 
inverse.com | Wei Gordon |Nadav Ahituv
People around the world eat too much sugar. When the body is unable to process sugar effectively, leading to excess glucose in the blood, this can result in diabetes. According to the World Health Organization, diabetes became the ninth leading cause of death in 2019. Humans are not the only mammals that love sugar. Fruit bats do, too, eating up to twice their body weight in sugary fruit a day. However, unlike humans, fruit bats thrive on a sugar-rich diet.
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Jan 18, 2024 | 
thepanamanews.com | Wei Gordon |Menlo College |Nadav Ahituv
Fruit bats have honed their sweet tooth through adaptive evolution. Keith Rose/iStock via Getty Images PlusWhy don’t fruit bats get diabetes? New understanding of how they’veadapted to a high-sugar diet could lead to treatments for peopleby Wei Gordon, Menlo College and Nadav Ahituv, University of California, San FranciscoPeople around the world eat too much sugar. When the body is unable to process sugar effectively, leading to excess glucose in the blood, this can result in diabetes.
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Jan 15, 2024 | 
zmescience.com | Wei Gordon |Nadav Ahituv
Wei Gordon and Nadav Ahituv Dr. Gordon is Assistant Professor of Biology at Menlo College. This is her first year teaching at Menlo College. Dr. Gordon went to graduate school to become an undergraduate professor and work at a student-focused institution.
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Jan 14, 2024 | 
malaysia.news.yahoo.com | Wei Gordon |Menlo College |Nadav Ahituv
People around the world eat too much sugar. When the body is unable to process sugar effectively, leading to excess glucose in the blood, this can result in diabetes. According to the World Health Organization, diabetes became the ninth leading cause of death in 2019. Humans are not the only mammals that love sugar. Fruit bats do, too, eating up to twice their body weight in sugary fruit a day. However, unlike humans, fruit bats thrive on a sugar-rich diet.
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Jan 12, 2024 | 
discovermagazine.com | Nadav Ahituv
We are a team of biologists and bioengineers . Determining how fruit bats evolved to specialize on a high-sugar diet sent us on a quest to approach diabetes therapy from an unusual angle - one that sent us all the way to Lamanai, Belize, for the Belize Bat-a-thon , an annual gathering where researchers collect and study bats.
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Jan 11, 2024 | 
dnronline.com | Wei Gordon |Nadav Ahituv
(The Conversation is an independent and nonprofit source of news, analysis and commentary from academic experts.)(THE CONVERSATION) People around the world eat too much sugar. When the body is unable to process sugar effectively, leading to excess glucose in the blood, this can result in diabetes. According to the World Health Organization, diabetes became the ninth leading cause of death in 2019. Humans are not the only mammals that love sugar.
