Nawsad Alam

Dec 20, 2023 | nature.com | Brendan Farrell |Nawsad Alam |Melissa Hart |Robert J. Ragotte |Simon Draper |Ellen Knuepfer

AbstractThe symptoms of malaria occur during the blood stage of infection, when parasites invade and replicate within human erythrocytes. The PfPCRCR complex1, containing PfRH5 (refs. 2,3), PfCyRPA, PfRIPR, PfCSS and PfPTRAMP, is essential for erythrocyte invasion by the deadliest human malaria parasite, Plasmodium falciparum. Invasion can be prevented by antibodies3,4,5,6 or nanobodies1 against each of these conserved proteins, making them the leading blood-stage malaria vaccine candidates.