Neal Jiwnani

Dec 2, 2024 | biorxiv.org | Devon Mason |Thomas D. Madsen |Alexander N. Gasparski |Neal Jiwnani

AbstractmRNA localization to specific subcellular regions is common in mammalian cells but poorly understood in terms of its physiological roles. This study demonstrates the functional importance of Net1 mRNA, which we find prominently localized at the dermal-epidermal junction (DEJ) in stratified squamous epithelia. Net1 mRNA accumulates at DEJ protrusion-like structures that interact with the basement membrane and connect to a mechanosensitive network of microfibrils.