Thomas D. Madsen

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Articles

Map of the Neuronal O-glycoproteome Reveal Driver Functions in the Regulated Secretory Pathway

1 month ago | jbc.org | Thomas D. Madsen |John Hintze |Emily J. Shiplett |Leo A. Dworkin

Introduction:Glycosylation is the most abundant and diverse type of posttranslational modification (PTM) of proteins, and glycans serve a plethora of roles in fine-tuning protein functions and serving as ligands in important interactions (1, 2).
Control of Epithelial Tissue Organization by mRNA Localization

Dec 2, 2024 | biorxiv.org | Devon Mason |Thomas D. Madsen |Alexander N. Gasparski |Neal Jiwnani

AbstractmRNA localization to specific subcellular regions is common in mammalian cells but poorly understood in terms of its physiological roles. This study demonstrates the functional importance of Net1 mRNA, which we find prominently localized at the dermal-epidermal junction (DEJ) in stratified squamous epithelia. Net1 mRNA accumulates at DEJ protrusion-like structures that interact with the basement membrane and connect to a mechanosensitive network of microfibrils.
Justisministeren skryter av storsatsing på politiet. Vi vet at det er løgn

Nov 13, 2023 | dt.no | Jon E. Torp |Stine M Bergan |Thomas D. Madsen |Politiets Fellesforbund Sør-Øst

Meninger Justisministeren skryter av storsatsing på politiet. Vi og våre medlemmer vet at det er løgn. Regjeringen holder Norges befolkning for narr. Forslaget i revidert statsbudsjett dekker kun lønns og prisveksten i politiet. Det betyr at dagens situasjon består og medfører at Sør-Øst politidistrikt er strukket til det ytterste for å kunne levere på samfunnsoppdraget. Når ryker den strikken? Per uke 44 var det 462 nyutdannede fra Politihøgskolen som sto uten jobb.
Regjeringen holder Norges befolkning for narr

Nov 13, 2023 | dt.no | Jon E. Torp |Stine M Bergan |Thomas D. Madsen |Politiets Fellesforbund Sør-Øst

Meninger Justisministeren skryter av storsatsing på politiet. Vi og våre medlemmer vet at det er løgn. Regjeringen holder Norges befolkning for narr. Forslaget i revidert statsbudsjett dekker kun lønns og prisveksten i politiet. Det betyr at dagens situasjon består og medfører at Sør-Øst politidistrikt er strukket til det ytterste for å kunne levere på samfunnsoppdraget. Når ryker den strikken? Per uke 44 var det 462 nyutdannede fra Politihøgskolen som sto uten jobb.
Fusion-negative rhabdomyosarcoma orthotopic tongue xenografts for study of invasion, intravasation and metastasis in live animals

Nov 10, 2023 | biorxiv.org | Sarah M Hammoudeh |Yeap Ng |Bih-Rong Wei |Thomas D. Madsen

AbstractPAX3/7 Fusion-negative rhabdomyosarcoma (FN-RMS) is a childhood mesodermal lineage malignancy with a poor prognosis for metastatic or relapsed cases. Towards achieving a more complete understanding of advanced FN-RMS, we developed an orthotopic tongue xenograft model for studies of molecular basis of FN-RMS invasion and metastasis.
Sør-Øst politidistrikt balanser på kanten av et stup

Nov 9, 2023 | varden.no | Thomas D. Madsen |Jon E. Torp |Stine M Bergan

Sør-Øst politidistrikt balanser på kanten av et stup Foto: Andreas Soltvedt Jon E. Torp Lokallagsleder PF Sør-Øst Thomas Madsen Organisasjonssekretær Oppdatert: Akkurat nå Du leser nå et leserinnlegg. Det uttrykker innsenderens mening. Publisert: torsdag 9. november 2023 kl. 15:34 Oppdatert: Akkurat nå
WITHDRAWN: Fusion-Negative Rhabdomyosarcoma xenografts in murine tongue provide a model for the study of local invasion, intravasation and metastasis at cellular and subcellular levels in live animals

Oct 9, 2023 | biorxiv.org | Sarah M Hammoudeh |Yeap Ng |Bih-Rong Wei |Thomas D. Madsen

AbstractThe authors have withdrawn their manuscript owing to questions about 2 panels within one figure. Therefore, the authors do not wish this work to be cited as reference for the project. If you have any questions, please contact the corresponding author. Competing Interest StatementThe authors have declared no competing interest.
Manganese Exacerbates Seasonal Health Declines in a Suicidally Breeding Mammal

Sep 26, 2023 | setac.onlinelibrary.wiley.com | Amanda C. Niehaus |Skye F. Cameron |Beata Ujvari |Thomas D. Madsen

INTRODUCTION Reproduction is so costly that organisms typically distribute their efforts and offspring over time to accommodate the competing energetic demands of growth and survival, and delay breeding during periods of poor health or environmental stress (Koons et al., 2008; Tuljapurkar, 1990). However, not all species hold back for the future—some invest all resources into a single (usually promiscuous) bout of breeding and then die.
Growth factor-induced desialylation for the fast control of endocytosis

Sep 13, 2023 | biorxiv.org | Ewan MacDonald |Alison Forrester |Cesar Augusto Valades-Cruz |Thomas D. Madsen

AbstractIt is commonly assumed that the glycan makeup of glycoproteins that reach the cell surface is final and static. Here, we challenge this notion by the discovery of a molecular switch that induces acute and reversible changes of glycans on the plasma membrane. We demonstrate that within minutes, the epidermal growth factor triggers the galectin-driven endocytosis of cell surface glycoproteins, such as integrins, that are key regulators of cell adhesion and migration.