Neranjan de Silva

Jan 15, 2025 | biorxiv.org | Lauretta A. Lacko |Tansol Choi |Neranjan de Silva |Ying Liu

Abstract3-dimensional (3D) imaging is a powerful tool for interrogation of intact tissues, but can suffer from poor resolution due to impediments such as high tissue autofluorescence that remains a significant challenge in imaging cleared samples, including human clinical specimens. We developed Atacama Clear (ATC), a 3D imaging technology that increases signal-to-noise ratios (SNRs) while simultaneously augmenting the capacity of tissue to be cleared.