Nicholas DeGroff

1 month ago | elifesciences.org | Olivia Taylor |Nicholas DeGroff |Heithem M. El-Hodiri |Chengyu Gao

eLife Assessment This important study investigates the signaling pathways regulating retinal regeneration. Convincing evidence shows that the sphingosine-1-phosphate (S1P) signaling pathway is inhibited following retinal injury. Small-molecule activators and inhibitors support a model in which S1P signaling must be inhibited to generate Müller glial progenitor cells-a key step in retinal regeneration. The presented results support the major conclusions.