Heithem M. El-Hodiri

1 month ago | elifesciences.org | Olivia Taylor |Nicholas DeGroff |Heithem M. El-Hodiri |Chengyu Gao

eLife Assessment This important study investigates the signaling pathways regulating retinal regeneration. Convincing evidence shows that the sphingosine-1-phosphate (S1P) signaling pathway is inhibited following retinal injury. Small-molecule activators and inhibitors support a model in which S1P signaling must be inhibited to generate Müller glial progenitor cells-a key step in retinal regeneration. The presented results support the major conclusions.

Oct 24, 2024 | onlinelibrary.wiley.com | Olivia Taylor |Heithem M. El-Hodiri |Isabella Palazzo |Levi Todd

1 INTRODUCTION Müller glia (MG) are the predominant type of support cell in the retina and are found in the retinas of all vertebrate classes. MG have many important functions that include structural support, synaptic support, osmotic homeostasis, and nutritive/metabolic support to retinal neurons (Bringmann et al., 2006; Jadhav et al., 2006; Newman, 1996; Vecino et al., 2016).