Nicholas Kwaan

Mar 26, 2024 | jci.org | Simon Cleary |Yurim Seo |Jennifer Tian |Nicholas Kwaan

ResearchPulmonologyTransplantationOpen Access | 10.1172/JCI178351 J Clin Invest. https://doi.org/10.1172/JCI178351. Copyright © 2024, Cleary et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

Jan 27, 2024 | biorxiv.org | Simon Cleary |Yurim Seo |Jennifer Tian |Nicholas Kwaan

AbstractAntibodies can initiate lung injury in a variety of disease states such as autoimmunity, transfusion reactions, or after organ transplantation, but the key factors determining in vivo pathogenicity of injury-inducing antibodies are unclear. A previously overlooked step in complement activation by IgG antibodies has been elucidated involving interactions between IgG Fc domains that enable assembly of IgG hexamers, which can optimally activate the complement cascade.