Yurim Seo

Oct 15, 2024 | jci.org | S. Farshid Moussavi-Harami |Simon Cleary |Mélia Magnen |Yurim Seo

ResearchImmunologyPulmonologyOpen Access | 10.1172/JCI183161 J Clin Invest. https://doi.org/10.1172/JCI183161. Copyright © 2024, Moussavi-Harami et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

May 28, 2024 | biorxiv.org | Simon Cleary |Mélia Magnen |Yurim Seo |S. Farshid Moussavi-Harami

AbstractThe acute respiratory distress syndrome (ARDS) is associated with significant morbidity and mortality and neutrophils are critical to its pathogenesis. Neutrophil activation is closely regulated by inhibitory tyrosine phosphatases including Src homology region 2 domain containing phosphatase-1 (Shp1).

Mar 26, 2024 | jci.org | Simon Cleary |Yurim Seo |Jennifer Tian |Nicholas Kwaan

ResearchPulmonologyTransplantationOpen Access | 10.1172/JCI178351 J Clin Invest. https://doi.org/10.1172/JCI178351. Copyright © 2024, Cleary et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

Jan 27, 2024 | biorxiv.org | Simon Cleary |Yurim Seo |Jennifer Tian |Nicholas Kwaan

AbstractAntibodies can initiate lung injury in a variety of disease states such as autoimmunity, transfusion reactions, or after organ transplantation, but the key factors determining in vivo pathogenicity of injury-inducing antibodies are unclear. A previously overlooked step in complement activation by IgG antibodies has been elucidated involving interactions between IgG Fc domains that enable assembly of IgG hexamers, which can optimally activate the complement cascade.