Nicola Flaum

May 22, 2023 | jmg.bmj.com | Nicola Flaum |Emma J. Crosbie |Emma Woodward |Fiona Lalloo

Article The inherited landscape of epithelial ovarian cancer (EOC) is well established with contributions from homologous recombination deficiency (HRD) genes, particularly BRCA1 and BRCA2, and mismatch repair deficiency (MMRD) genes MSH2, MLH1, MSH6 and PMS2.1 High-grade serous ovarian cancer (HGSOC) is associated with HRD, accounting for up to 23% of HGSOC.2 Approximately 3% of EOC cases occur in <30 years of age, described as very young onset ovarian cancer (VYOC).1 The pathology in VYOC...

May 18, 2023 | gimjournal.org | Nicola Flaum |John Bowes |Miriam Smith |Emma J. Crosbie

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