Nicolas Fonta

Jul 13, 2024 | biorxiv.org | Nicolas Fonta |Nicolas Page |Bogna Klimek |Margot Piccinno

AbstractIn chronic inflammatory disorders of the central nervous system (CNS), tissue-resident self-reactive T cells perpetuate disease. The specific tissue factors governing the persistence and continuous differentiation of these cells remain undefined but could represent attractive therapeutic targets. In a model of chronic CNS autoimmunity, we find that oligodendrocyte-derived interleukin-33 (IL-33), an alarmin, is key for locally regulating the pathogenicity of self-reactive CD8+ T cells.