Nicolas Page

Jul 13, 2024 | biorxiv.org | Nicolas Fonta |Nicolas Page |Bogna Klimek |Margot Piccinno

AbstractIn chronic inflammatory disorders of the central nervous system (CNS), tissue-resident self-reactive T cells perpetuate disease. The specific tissue factors governing the persistence and continuous differentiation of these cells remain undefined but could represent attractive therapeutic targets. In a model of chronic CNS autoimmunity, we find that oligodendrocyte-derived interleukin-33 (IL-33), an alarmin, is key for locally regulating the pathogenicity of self-reactive CD8+ T cells.

May 30, 2023 | nature.com | Thomas Gruber |Nicolas Page |Nicolas Blanchard |Markus Schwaninger |Mirjam Schenk |Doron Merkler | +2 more

AbstractBlood-brain barrier (BBB) breakdown and immune cell infiltration into the central nervous system (CNS) are early hallmarks of multiple sclerosis (MS). High numbers of CD8+ T cells are found in MS lesions, and antigen (Ag) presentation at the BBB has been proposed to promote CD8+ T cell entry into the CNS. Here, we show that brain endothelial cells process and cross-present Ag, leading to effector CD8+ T cell differentiation.