Nicolas Goldbach

May 9, 2024 | nature.com | Erin Yang |Marcos Miranda |Andrew J. Borst |Jason Zhang |Nicolas Goldbach |Maggie Ahlrichs | +5 more

AbstractProgramming protein nanomaterials to respond to changes in environmental conditions is a current challenge for protein design and is important for targeted delivery of biologics. Here we describe the design of octahedral non-porous nanoparticles with a targeting antibody on the two-fold symmetry axis, a designed trimer programmed to disassemble below a tunable pH transition point on the three-fold axis, and a designed tetramer on the four-fold symmetry axis.