Nigel Jamieson

Nov 27, 2024 | cell.com | Lucy Macdonald |Aziza Elmesmari |Domenico Somma |Jack Frew |Clara Di Mario |Roopa Madhu | +30 more

Keywordsimmune tolerancearthritisdisease remissiondendritic cellssynovial tissuespatial transcriptomicsT cellsIntroductionRheumatoid arthritis (RA) is an inflammatory joint disease with systemic comorbidities, driven by the breach of immune tolerance.1 Advances in targeted therapies2 have transformed the management of RA.

Jul 7, 2024 | biorxiv.org | Natalie Fisher |Sudhir B. Malla |Nigel Jamieson |Philip Dunne

AbstractIn an era where transcriptomics-based subtyping, phenotyping and mechanistic understanding is increasingly being driven by state-of-the-art spatially resolved transcriptomic (ST) technologies, it is imperative that researchers, journals, and funders do all they can to ensure that as a community we are interpreting these exciting data as accurately as possible with awareness of their limitations.