Nigel S. Scrutton

Oct 14, 2024 | chemistry-europe.onlinelibrary.wiley.com | Nigel S. Scrutton |Sam Hay

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Aug 21, 2023 | nature.com | Derren J. Heyes |Muralidharan Shanmugam |Linus O Johannissen |Laura N Jeffreys |Sam Hay |Nigel S. Scrutton | +2 more

AbstractCarH is a coenzyme B12-dependent photoreceptor involved in regulating carotenoid biosynthesis. How light-triggered cleavage of the B12 Co-C bond culminates in CarH tetramer dissociation to initiate transcription remains unclear. Here, a series of crystal structures of the CarH B12-binding domain after illumination suggest formation of unforeseen intermediate states prior to tetramer dissociation.