Linus O Johannissen

Mar 2, 2025 | dx.doi.org | José Lucas Sena |Linus O Johannissen |Jonny J. Blaker |Sam Hay

IntroductionClick to copy section linkSection link copied!Understanding the interaction of water with surfaces can be approached in diverse ways depending on the application. This interaction can be broadly categorized into two major categories, depending on the level of wetting of the surface: hydrophilic and hydrophobic.

Mar 2, 2025 | pubs.acs.org | José Lucas Sena |Linus O Johannissen |Jonny J. Blaker |Sam Hay

IntroductionClick to copy section linkSection link copied!Understanding the interaction of water with surfaces can be approached in diverse ways depending on the application. This interaction can be broadly categorized into two major categories, depending on the level of wetting of the surface: hydrophilic and hydrophobic.

Mar 4, 2024 | nature.com | Florence Hardy |Linus O Johannissen |Richard Obexer |Sam Hay

AbstractDirected evolution of computationally designed enzymes has provided new insights into the emergence of sophisticated catalytic sites in proteins. In this regard, we have recently shown that a histidine nucleophile and a flexible arginine can work in synergy to accelerate the Morita-Baylis-Hillman (MBH) reaction with unrivalled efficiency.

Aug 21, 2023 | nature.com | Derren J. Heyes |Muralidharan Shanmugam |Linus O Johannissen |Laura N Jeffreys |Sam Hay |Nigel S. Scrutton | +2 more

AbstractCarH is a coenzyme B12-dependent photoreceptor involved in regulating carotenoid biosynthesis. How light-triggered cleavage of the B12 Co-C bond culminates in CarH tetramer dissociation to initiate transcription remains unclear. Here, a series of crystal structures of the CarH B12-binding domain after illumination suggest formation of unforeseen intermediate states prior to tetramer dissociation.