Nikita Kadakia

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Integrating genetics with single-cell multiomic measurements across disease states identifies mechanisms of beta cell dysfunction in type 2 diabetes - Nature Genetics

May 25, 2023 | nature.com | Joshua Chiou |Jee Yun Han |Nikita Kadakia |Joan Camunas-Soler |Theodore dos Santos |Seung K. Kim | +2 more

AbstractDysfunctional pancreatic islet beta cells are a hallmark of type 2 diabetes (T2D), but a comprehensive understanding of the underlying mechanisms, including gene dysregulation, is lacking. Here we integrate information from measurements of chromatin accessibility, gene expression and function in single beta cells with genetic association data to nominate disease-causal gene regulatory changes in T2D.

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