Theodore dos Santos

Jan 7, 2025 | cell.com | Jessica D. Ewald |Yao Lu |Cara E. Ellis |Jessica Worton |Jelena Kolic |Shugo Sasaki | +25 more

ForumVolume 37, Issue 1p7-11 1Institute of Parasitology, McGill University, Montreal, QC, Canada 2Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA 3Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada 4Department of Pharmacology, University of Alberta, Edmonton, AB, Canada 5Department of Surgery, University of Alberta, Edmonton, AB, Canada 6Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia,...

Jan 7, 2025 | cell.com | Jessica D. Ewald |Yao Lu |Cara E. Ellis |Jessica Worton |Jelena Kolic |Shugo Sasaki | +25 more

ForumVolume 37, Issue 1p7-11 1Institute of Parasitology, McGill University, Montreal, QC, Canada 2Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA 3Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada 4Department of Pharmacology, University of Alberta, Edmonton, AB, Canada 5Department of Surgery, University of Alberta, Edmonton, AB, Canada 6Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia,...

May 25, 2023 | nature.com | Joshua Chiou |Jee Yun Han |Nikita Kadakia |Joan Camunas-Soler |Theodore dos Santos |Seung K. Kim | +2 more

AbstractDysfunctional pancreatic islet beta cells are a hallmark of type 2 diabetes (T2D), but a comprehensive understanding of the underlying mechanisms, including gene dysregulation, is lacking. Here we integrate information from measurements of chromatin accessibility, gene expression and function in single beta cells with genetic association data to nominate disease-causal gene regulatory changes in T2D.