Ning Zheng

Feb 12, 2025 | nature.com | Xiaowen Xie |Olivia Zhang |Ceejay Lee |N. Connor Payne |Leena Paul |Yiran Li | +10 more

AbstractCancer mutations can create neomorphic protein–protein interactions to drive aberrant function1,2. As a substrate receptor of the CULLIN3-RING E3 ubiquitin ligase complex, KBTBD4 is recurrently mutated in medulloblastoma3, the most common embryonal brain tumour in children4. These mutations impart gain-of-function to KBTBD4 to induce aberrant degradation of the transcriptional corepressor CoREST5. However, their mechanism remains unresolved.

Apr 19, 2024 | nature.com | Feng Liu |Ning Zheng

AbstractDue to their exceptional manufacturability and excellent mechanical properties, epoxy thermosets are one of the most widely used plastics, finding many industrial applications. However, the crosslinked polymer network renders them inherently brittle and not recyclable, raising sustainability concerns. Here we show epoxy thermosets with combined high toughness and reprocessability by innovating the chemistry of curing, a crosslinking process in polymers.

Nov 14, 2023 | mdpi.com | Meng Wang |Ning Zheng |Xuan Li |Kun Zhao

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