Nivedita Hariharan

Jul 25, 2024 | biorxiv.org | Michelle D'souza |Nivedita Hariharan |Syed Wasifa Qadri |Dasaradhi Palakodeti

AbstractThe Fragile X Messenger Ribonucleoprotein (FMRP) is a selective RNA-binding protein that localizes to the cytoplasm and the nucleus. The loss of FMRP results in Fragile X Syndrome (FXS), an Autism Spectrum Disorder. FMRP interacts with ribosomes and regulates the translation of mRNAs essential for neuronal development and synaptic plasticity. However, the biochemical nature of this translation regulation is unknown.