Dasaradhi Palakodeti

Nov 18, 2024 | biorxiv.org | Tripti Kharbanda |Michelle D'souza |Dasaradhi Palakodeti |Ravi S Muddashetty

AbstractFragile X Messenger Ribonucleoprotein 1 (FMRP) is a multifunctional, multidomain RNA-binding protein whose loss causes Fragile X syndrome. It is also known to associate with ribosomes and modulate translation. In human embryonic stem cells (hESCs), knockout (KO) of the FMR1 gene results in significantly increased protein translation rates and alterations in the 2′-O-methylation patterns of rRNA.

Jul 25, 2024 | biorxiv.org | Michelle D'souza |Nivedita Hariharan |Syed Wasifa Qadri |Dasaradhi Palakodeti

AbstractThe Fragile X Messenger Ribonucleoprotein (FMRP) is a selective RNA-binding protein that localizes to the cytoplasm and the nucleus. The loss of FMRP results in Fragile X Syndrome (FXS), an Autism Spectrum Disorder. FMRP interacts with ribosomes and regulates the translation of mRNAs essential for neuronal development and synaptic plasticity. However, the biochemical nature of this translation regulation is unknown.