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Nov 26, 2024 | 
elifesciences.org | Marco Palombo |Bharath Krishnan |Noah Cowan |Maëliss Jallais
Quantifying confidence in an estimate is of crucial importance. As demonstrated by our pathological example, changes in the tissue microstructure parameters can help clinicians decide which parameters are the most reliable and better interpret microstructure changes within diseased tissue. On large population studies, the quantified uncertainty can be taken into account when performing group statistics and to detect outliers. Multiple approaches have been used to try and quantify this uncertainty.
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Nov 25, 2024 | 
elifesciences.org | Bharath Krishnan |Noah Cowan |Jiayun Xu |Elena Massai
When moving through an environment, we often use visual landmarks – such as a specific store or street sign – to guide us and determine our next action (Tolman et al., 1946a). However, the brain does not just rely on visual landmarks for navigation.
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Nov 19, 2024 | 
biorxiv.org | Huanying Yeh |Yu Yang |Debojyoti Biswas |Noah Cowan
AbstractTo execute sensory-guided behavior, the nervous system must manage uncertainty within multiple streams of information. There are two highly nonlinear mechanisms for achieving this: 1) sensory reweighting, an internal neural computation which places more emphasis on sensory information that exhibits the least uncertainty, e.g. in a Bayesian framework, and 2) active sensing, an overt behavior that seeks to improve the quality of sensory information before it enters the nervous system.
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Oct 30, 2024 | 
biorxiv.org | Di Cao |Noah Cowan |Amy J. Bastian |Kyunggeune Oh
AbstractIndividuals with cerebellar ataxia often face significant challenges in controlling reaching, especially when multijoint movements are involved. This study investigated the effects of kinematic and dynamic demands on reaching movements by individuals with cerebellar ataxia and healthy controls using a virtual reality task. Participants reached to target locations designed to elicit a range of coordination strategies between shoulder and elbow joint movements.
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Oct 17, 2024 | 
biorxiv.org | Yu Yang |Debojyoti Biswas |Noah Cowan |Huanying Yeh
AbstractAnimals integrate multiple sensory inputs to explore environments and execute locomotor behaviors. To carry out these behaviors, the nervous system internally reweights controller gains, putting more emphasis on those with the least uncertainty, e.g. in a Bayesian framework. Meanwhile, as sensory uncertainty increases, animals produce more vigorous active sensing movements.
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Sep 4, 2024 | 
nature.com | Ruohong Shi |Siming Deng |Noah Cowan |David H. Gracias
AbstractThe ability to transform matter between numerous physical states or shapes without wires or external devices is a major challenge for robotics and materials design. Organisms can transform their shapes using biomolecules carrying specific information and localize at sites where transitions occur. Here, we introduce gel automata, which likewise can transform between a large number of prescribed shapes in response to a combinatorial library of biomolecular instructions.
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Apr 30, 2024 | 00459-7?rss=yes&sz=64)
cell.com | Johns Hopkins |Dominic G. Yared |Eric Fortune |Noah Cowan
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Feb 12, 2024 | 
biorxiv.org | James J. Knierim |Noah Cowan |Johns Hopkins |Gorkem Secer
AbstractInternal representations of continuous variables are crucial to create internal models of the external world. A prevailing model of how brain maintains these representations is given by continuous bump attractor networks (CBANs). CBANs have been hypothesized as an underlying mechanism in a broad range of brain functions across different areas, such as spatial navigation in hippocampal/entorhinal circuits and working memory in prefrontal cortex.
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Mar 16, 2023 | 
filmmakermagazine.com | Noah Cowan
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Mar 16, 2023 | 
filmmakermagazine.com | Noah Cowan
If your favorite films don’t show idiosyncratic tastes, you’re not alive. It means you’re just in a bubble of the culture and your own anxieties about what you think is real and not real. Whereas if you were to be honest about what’s important to you, it would have to be the things that actually make your heart sing, which is why I’m always suspicious of people who do a 10-best list that doesn’t have at least two titles from childhood. Was it really that bad?
