Noah R. Sommers

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Coordination between the eIF2 kinase GCN2 and p53 signaling supports purine metabolism and the progression of prostate cancer

Nov 26, 2024 | science.org | Ricardo Cordova |Annalisa M. VanHook |Noah R. Sommers |Andrew Law

Editor’s summaryThe integrated stress response (ISR) enables tumor cells to adapt quickly to their tissue environment, thus supporting cell survival and tumor progression. Cordova et al. found that inhibiting the ISR kinase GCN2 kills prostate cancer cells deficient in the transcription factor p53. GCN2 inhibition decreased the availability of amino acids that are used in purine nucleotide synthesis.

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