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3 weeks ago | 
science.org | Sigal B. Kofman |Annalisa M. VanHook |Lan Chu |Joshua Ames
Editor’s summaryIn contrast with proliferating cells, the activation of the RHIM domain–containing kinase RIPK3 in neurons does not induce necroptosis but rather an antiviral transcriptional response. Kofman et al. investigated the molecular mechanisms underlying this response. In cortical neurons, the RIPK3-dependent transcriptional response required other RHIM domain–containing proteins, RIPK1 and TRIF, that are also critical for necroptosis in proliferating cells.
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3 weeks ago | 
science.org | Sigal B. Kofman |Annalisa M. VanHook
AbstractEthanol impairs sleep in fruit flies by inhibiting cholinergic neurons. SIGN UP FOR THE AWARD-WINNING SCIENCEADVISER NEWSLETTER The latest news, commentary, and research, free to your inbox daily Although ethanol induces drowsiness, it also disrupts sleep. In patients with alcohol use disorder, sleep deficits may persist for weeks after alcohol consumption ceases.
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2 months ago | 
science.org | Shixin Ma |Léa Meneu |Hongbo Liu |Ian S. Osborne |Michael Funk |Madeleine Seale | +11 more
Topological Optics Viewing topology in higher dimensionsIan S. OsborneArtistic depiction of a four-dimensional regular lattice that forms a quasicrystalline pattern with fivefold symmetry when projected in two dimensions. The symmetry and topology of physical systems are closely related to the symmetries governing the topological properties. Quasicrystals are ordered systems but have no translation or rotational symmetries.
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Dec 19, 2024 | 
science.org | Michael Funk |Ian S. Osborne |Jake Yeston |Madeleine Seale |Sarah Ross |Di Jiang | +7 more
Optomechanics Motions of the quantum collectiveIan S. OsborneMicro- and nanomechanical oscillators can now be manipulated in the quantum regime. They can be entangled with other degrees of freedom and used for quantum teleportation and quantum storage. To date, these systems have been limited to single or pairs of oscillators. Chegnizadeh et al. now demonstrate scale-up, preparing a collective macroscopic system composed of several individual mechanical oscillators in the quantum ground state.
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Nov 26, 2024 | 
science.org | Ricardo Cordova |Annalisa M. VanHook |Noah R. Sommers |Andrew Law
Editor’s summaryThe integrated stress response (ISR) enables tumor cells to adapt quickly to their tissue environment, thus supporting cell survival and tumor progression. Cordova et al. found that inhibiting the ISR kinase GCN2 kills prostate cancer cells deficient in the transcription factor p53. GCN2 inhibition decreased the availability of amino acids that are used in purine nucleotide synthesis.
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Oct 22, 2024 | 
science.org | Teresa Rosenlehner |Jinshan Zhang |Annalisa M. VanHook |Yawen Zhao
Editor’s summaryThe appetite-stimulating hormone ghrelin promotes hepatic lipid accumulation. Zhang et al. investigated the regulation of hepatic lipid homeostasis by Piezo1, a mechanosensitive ion channel that is activated when food ingestion stretches the stomach and that suppresses ghrelin production. Mice lacking Piezo1 in ghrelin-producing cells in the stomach developed hepatic steatosis, which was reversed by pharmacologically blocking the ghrelin receptor.
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Oct 22, 2024 | 
science.org | Teresa Rosenlehner |Jinshan Zhang |Annalisa M. VanHook
When a nuclear-replicating virus enters a host cell, the viral capsid docks onto the nuclear pore complex (NPC) to deliver the viral genome to the nucleus. For some viruses, such as human immunodeficiency virus 1 (HIV-1), the entire capsid translocates into the nucleus; for other viruses, like herpes simplex virus 1 (HSV-1), only the genome is released into the nucleus.
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Oct 22, 2024 | 
science.org | Teresa Rosenlehner |Jinshan Zhang |Annalisa M. VanHook |Stefanie Pennavaria
Editor’s summaryActivated T cells must ramp up ribosomal biogenesis in nucleoli to support protein synthesis required for proliferation. Rosenlehner et al. investigated the interplay among T cell receptor (TCR) signaling, ribosomal biosynthesis, and mTORC1, a multiprotein complex implicated in cell growth and proliferation. mTORC1 was required for the rapid cell cycling of proliferating activated T cells.
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Sep 17, 2024 | 
science.org | Shoukat Afshar-Sterle |Thomas Huber |Annalisa M. VanHook
Editors' ChoiceMETABOLISMAnnalisa M. VanHook https://orcid.org/0000-0002-5989-6767Authors Info & AffiliationsAbstractThe taurine metabolite N-acetyltaurine protects mice from diet-induced obesity by reducing food intake.
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Sep 17, 2024 | 
science.org | Shoukat Afshar-Sterle |Thomas Huber |Annalisa M. VanHook |Annalisa L.E. Carli
Editor’s summaryThe serine/threonine kinase DCLK1 is a putative cancer stem cell marker that is associated with the progression of gastric cancers. Afshar-Sterle et al. found that mutating the kinase domain of DCLK1 or inhibiting its kinase activity reduced tumor growth, abundance of markers of stromal remodeling, and induction of epithelial-to-mesenchymal transition (EMT).
