Nobuyuki Okahashi

Sep 18, 2024 | nature.com | Munehiro Furuichi |Takaaki Kawaguchi |Keiko Yasuma-Mitobe |Damian R. Plichta |Masahiro Ueda |Nobuyuki Okahashi | +10 more

AbstractPersistent colonization and outgrowth of potentially pathogenic organisms in the intestine can result from long-term antibiotic use or inflammatory conditions, and may perpetuate dysregulated immunity and tissue damage1,2. Gram-negative Enterobacteriaceae gut pathobionts are particularly recalcitrant to conventional antibiotic treatment3,4, although an emerging body of evidence suggests that manipulation of the commensal microbiota may be a practical alternative therapeutic strategy5,6,7.

Feb 14, 2023 | biorxiv.org | Yuya Kondo |Nobuyuki Okahashi |Tomoki Shima |Chie Araki

New Results doi: https://doi.org/10.1101/2021.11.16.468557 AbstractAdenosine triphosphate (ATP) regeneration by substrate-level phosphorylation is a general feature of cancer metabolism, even under normoxic conditions (aerobic glycolysis). However, it is unclear why cancer cells prefer inefficient aerobic glycolysis over the highly efficient process of oxidative phosphorylation for ATP regeneration.