Noel C. Chan

Jan 2, 2024 | onlinecjc.ca | Alejandro Godoy |Noel C. Chan |John Eikelboom |Jack Hirsh |Vinai Bhagirath

Clinical trials are performed with the aim of improving patient care. Occasionally, the results are sufficiently convincing to change clinical practice. The recently published FRAIL-AF trial reported that patients with atrial fibrillation (AF) and frailty who have stable international normalized ratio (INR) would be safer to remain on vitamin K antagonists (VKAs) rather than being switched to a direct oral anticoagulant (DOAC),1.

Aug 16, 2023 | jacc.org | Noel C. Chan |John Eikelboom

IntroductionMost acute ischemic arterial events are a result of atherosclerotic plaque disruption with superimposed thrombus formation or embolism from the heart, and guidelines provide evidence-based recommendations for their diagnosis and management. Less commonly, acute ischemic arterial events occur in patients who do not have atherosclerosis or an identified embolic source and seem to be otherwise unexplained.

Jul 8, 2023 | pubmed.ncbi.nlm.nih.gov | Noel C. Chan |Ke Xu

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