Norazizah Shafee

Jan 25, 2024 | nature.com | Michael Nguyen |Norazizah Shafee |Katarzyna Dobaczewska |Sara McArdle |Sarah R. Leist |Kenneth Kim | +3 more

AbstractSARS-CoV-2-reactive T cells are detected in some healthy unexposed individuals. Human studies indicate these T cells could be elicited by the common cold coronavirus OC43. To directly test this assumption and define the role of OC43-elicited T cells that are cross-reactive with SARS-CoV-2, we develop a model of sequential infections with OC43 followed by SARS-CoV-2 in HLA-B*0702 and HLA-DRB1*0101 Ifnar1−/− transgenic mice.