Kenneth Kim

Jan 8, 2025 | nature.com | Farhoud Faraji |Sydney I. Ramirez |Kuniaki Sato |Kenneth Kim |Quinton Smith |Ophir Klein

AbstractTumor initiation represents the first step in tumorigenesis during which normal progenitor cells undergo cell fate transition to cancer. Capturing this process as it occurs in vivo, however, remains elusive. Here we employ spatiotemporally controlled oncogene activation and tumor suppressor inhibition together with multiomics to unveil the processes underlying oral epithelial progenitor cell reprogramming into tumor initiating cells at single cell resolution.

Jan 25, 2024 | nature.com | Michael Nguyen |Norazizah Shafee |Katarzyna Dobaczewska |Sara McArdle |Sarah R. Leist |Kenneth Kim | +3 more

AbstractSARS-CoV-2-reactive T cells are detected in some healthy unexposed individuals. Human studies indicate these T cells could be elicited by the common cold coronavirus OC43. To directly test this assumption and define the role of OC43-elicited T cells that are cross-reactive with SARS-CoV-2, we develop a model of sequential infections with OC43 followed by SARS-CoV-2 in HLA-B*0702 and HLA-DRB1*0101 Ifnar1−/− transgenic mice.