Oana Amarie

Dec 4, 2024 | nature.com | Tim Hasenbein |Sarah Hoelzl |Zachary Smith |Chiara Gerhardinger |Oana Amarie |Lore Becker | +9 more

AbstractThe lncRNA Crossfirre was identified as an imprinted X-linked gene, and is transcribed antisense to the trans-acting lncRNA Firre. The Firre locus forms an inactive-X-specific interaction with Dxz4, both loci providing the platform for the largest conserved chromatin structures. Here, we characterize the epigenetic profile of these loci, revealing them as the most female-specific accessible regions genome-wide.