Olesya Plazyo

Dec 6, 2023 | frontiersin.org | Mrinal K. Sarkar |Olesya Plazyo |Shruthi Shanmukha

Highlights● DNA damage accumulation is increased in blood mononuclear cells of PsA patients● Levels of DNA damage correlate with CRP levels in PsA● Type-I Interferon pathway is paradoxically downregulated in PsAIntroductionPsoriatic arthritis (PsA) is a common inflammatory arthropathy, affecting about 25% of patients with psoriasis. It is heterogenous with many clinical manifestations, including arthritis, skin psoriasis, enthesitis, nail involvement and dactylitis.

May 1, 2023 | jci.org | Kelly Young |Olesya Plazyo |Johann E. Gudjonsson |Qingyang Li

AbstractThe role of the vasculature in inflammatory skin disorders is an exciting area of investigation. Vascular endothelial cells (ECs) play instrumental roles in maintaining the vascular barrier and control of blood flow. Furthermore, ECs contribute to a variety of immune responses, such as targeting immune cells to specific areas of vascular damage, infection, or foreign material. However, mechanisms through which ECs participate in immune-mediated responses remain to be fully explored.