Olivia Platt

Oct 10, 2023 | nature.com | Carol M. Sheppard |Daniel H. Goldhill |Olivia Platt |Ksenia Sukhova |Thomas Peacock |Ervin Fodor

AbstractHuman ANP32A and ANP32B are essential but redundant host factors for influenza virus genome replication. While most influenza viruses cannot replicate in edited human cells lacking both ANP32A and ANP32B, some strains exhibit limited growth. Here, we experimentally evolve such an influenza A virus in these edited cells and unexpectedly, after 2 passages, we observe robust viral growth.