Olivia Stonehouse

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Clonal analysis of fetal hematopoietic stem/progenitor cells reveals how post-transplantation capabilities are distributed

Aug 1, 2024 | cell.com | Olivia Stonehouse |Christine Biben |Tom Weber |Alexandra L. Garnham

Highlights•Functional equivalents of adult stem/progenitor cells exist in the fetal liver•Large numbers of bona fide LT-RUs reside in the fetal ST-HSC population•Flt3-cre tracking indicated that multiple LT-RU-forming pathways existSummaryIt has been proposed that adult hematopoiesis is sustained by multipotent progenitors (MPPs) specified during embryogenesis.

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